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US7767449B1 Methods using modified vaccinia virus

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Recombinant Modified Vaccinia Virus Ankara Expressing the Spike Glycoprotein of Severe Acute Respiratory Syndrome Coronavirus Induces Protective .

In this study, we generated a SARS vaccine candidate by using the live-attenuated modified vaccinia virus Ankara (MVA) as a vector. The full-length SARS-CoV envelope Spike (S) glycoprotein gene was introduced into the deletion III region of the MVA genome. ...

Methods using modified vaccinia virus - Health Research Incorporat

What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous ...

US Patent for Modified vaccinia virus and methods for making and using the same Patent (Patent # 4,769,330 issued September 6, 1988) - Justia .

The present invention relates to modified vaccinia virus, to methods of making and using the same, and to other modified and unmodified microorganisms, and to certain DNA sequences, produced or involved as intermediates in the production of modified vaccinia ...

Large Scale Amplification and Purification of Replication Competent Vaccinia Vir

Suvi Vallius Large Scale Amplification and Purification of Replication Competent Vaccinia Virus Helsinki Metropolia University of Applied Sciences ... Abstract Author Title Number of Pages Date Suvi Vallius Large Scale Amplification and Purification of Replication ...

Modified vaccinia Ankara - Wikiped

One of them, the Modified Vaccinia Ankara (MVA') virus, is a highly attenuated strain of vaccinia virus that was developed towards the end of the campaign for the eradication of smallpox by Anton Mayr in Germany. Produced by more than 500 passages ofchicken ...

Methods using modified vaccinia virus - Patent - Europe P

Methods using modified vaccinia virus (PAT - US7767449) PAOLETTI ENZO HEALTH RESEARCH INC Patent: Reexamination Certificate First Reexamination - United States Application: US19940228926 on 1994-04-14 Publication: 2010-08-03 Abstract ...

Vaccinia Virus - an overview | ScienceDirect Topi

Kazuhide Uemura, ... Toshisuke Kawasaki, in Methods in Enzymology, 2003 Principles Vaccinia viruses are DNA viruses that infect almost all mammalian cells. The use of vaccinia virus as a vector to introduce cDNAs into mammalian cells has several useful ...

US7767449B1 - Methods using modified vaccinia virus - Google Paten

The present invention relates to modified vaccinia virus, to methods of making and using the same, and to other modified and unmodified microorganisms, ...

Large Scale Amplification and Purification of Replication Competent Vaccinia Vir

Suvi Vallius Large Scale Amplification and Purification of Replication Competent Vaccinia Virus Helsinki Metropolia University of Applied Sciences ... Abstract Author Title Number of Pages Date Suvi Vallius Large Scale Amplification and Purification of Replication ...

Efficiently Editing the Vaccinia Virus Genome by Using the CRISPR-Cas9 Syst

Vaccinia virus (VACV) continues to be used in immunotherapy for the prevention of infectious diseases and treatment of cancer since its use for the eradication of smallpox. However, the current method of editing the VACV genome is not efficient. Here, we ...

Development of a Novel Method to Express and Purify Vaccinia Virus Early Transcription Factors A7 and D6 using Bacter

Development of a Novel Method to Express and Purify Vaccinia Virus Early Transcription Factors A7 and D6 using Bacteria By Omkar M Gandbhir Submitted in partial fulfillment of the requirements for the degree of Masters of Sciences in Biology from the ...

κB activation by modified vaccinia virus as a novel HIV-specific T-cell respons

Although attenuated vaccinia virus (VACV) is a commonly used vector model for vaccine development (1), poxviruses ... Methods), using as a backbone the NYVAC-C vector expressing HIV-1 clade C antigens Env (gp120) as a cell-released product and Gag-Pol ...

Microbiology Society Journals | Modified vaccinia virus Ankara induces moderate activation of human dendritic cel

Modified vaccinia virus Ankara (MVA) is a highly attenuated strain known to be an effective vaccine vector. ... A functional measles virus replication and transcription machinery encoded by the vaccinia virus genome. J Virol Methods 79, 65 –74. [Google Scholar] ...

Purification of modified vaccinia virus Ankara from suspension cell culture | BMC Proceedings | Full Te

We investigated purification of modified vaccinia virus Ankara (MVA) produced on the continuous avian cell line CR.pIX. MVA is a versatile and highly immunogenic viral vector, but also known to pose unique challenges in production processes []. For example, the ...

Neutralization Assay Using a Modified Vaccinia Virus Ankara Vector Expressing the Green Fluorescent Protein Is a High-Throughput Method To .

Neutralization Assay Using a Modified Vaccinia Virus Ankara Vector Expressing the Green Fluorescent Protein Is a High-Throughput ... methods to measure anti-vaccinia virus neutralizing antibodies are usually performed using a plaque reduction neutralization ...

Vaccinia - Wikiped

Vaccinia virus (VACV or VV) is a large, complex, enveloped virus belonging to the poxvirus family. It has a linear, double-stranded DNA genome approximately 190 kbp in length, and which encodes approximately 250 genes. The dimensions of the virion are roughly ...

Vaccinia Virus - an overview | ScienceDirect Topi

Kazuhide Uemura, ... Toshisuke Kawasaki, in Methods in Enzymology, 2003 Principles Vaccinia viruses are DNA viruses that infect almost all mammalian cells. The use of vaccinia virus as a vector to introduce cDNAs into mammalian cells has several useful ...

Recombinant Modified Vaccinia Virus Ankara Expressing the Spike Glycoprotein of Severe Acute Respiratory Syndrome Coronavirus Induces Protective .

In this study, we generated a SARS vaccine candidate by using the live-attenuated modified vaccinia virus Ankara (MVA) as a vector. The full-length SARS-CoV envelope Spike (S) glycoprotein gene was introduced into the deletion III region of the MVA genome. ...

US 9675689 B2 - Genetically Stable Recombinant Modified Vaccinia Ankara (rmva) Vaccines And Methods Of Preparation Thereof - The Lens - Free .

A composition comprising: an immunologically effective amount of a recombinant modified vaccinia Ankara (rMVA) virus, wherein the rMVA virus comprises a fusion nucleotide sequence which encodes an IEfusion CMV protein antigen, said fusion nucleotide ...

Note for guidance on the development if vaccinia virus based vaccines against smallp

For the purpose of this document, smallpox vaccines, manufactured by growing vaccinia virus by one of the above methods, have been denoted as second generation smallpox vaccines. ...

Easy and Efficient Protocols for Working with Recombinant Vaccinia Virus MVA | SpringerLi

Modified vaccinia virus Ankara (MVA) is a highly attenuated and replication-deficient strain of vaccinia virus that is increasingly used as vector for expression of recombinant genes ...