logo

Role of lubricin and boundary lubrication in the

If you want to confirm some technical details before you order,
just need to send a message or e-mail: [email protected].
Then our professional sales staff will contact you within 2 hours.

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis | PN

These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatment to prevent cartilage deterioration in patients with genetic or ...

Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro | Scientific Repor

Waller, K. A. et al. Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. PNAS USA 110, 5852–5857 (2013). CAS PubMed Article Google Scholar 16. Flannery, C. R. et al. Prevention of cartilage degeneration in a rat model of. 60 ...

Boundary mode lubrication of articular cartilage by recombinant human lubricin - Gleghorn - 2009 - Journal of Orthopaedic Research - Wiley Online .

Lubrication of cartilage involves a variety of physical and chemical factors, including lubricin, a synovial glycoprotein that has been shown to be a boundary lubricant. It is unclear how lubricin boundary lubricates a wide range of bearings from tissue to artificial ...

Proteoglycan 4 - Wikiped

Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Lubricin ...

The role of lubricin in the mechanical behavior of synovial fluid | G D Jay | Request P

Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA–protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under load.

Full-Length Recombinant Human Proteoglycan 4 Interacts with Hyaluronan to Provide Cartilage Boundary Lubrication | SpringerLi

Full-Length Recombinant Human Proteoglycan 4 Interacts with Hyaluronan to Provide Cartilage Boundary Lubrication Authors Authors and affiliations ...

The role of lubricin in normal and pathological joint tissue: a contemporary revi

boundary lubrication of congruent articular surfaces under conditions of high contact pressure and near-zero sliding speed. ... The role of lubricin in normal and pathological joint tissue: a contemporary review. OA Anatomy 2013 Feb 01;1(1):2. rod and, in solution ...

Proteoglycan 4 - Wikiped

Function Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP).

The biology of Lubricin: Near frictionless joint motion - ScienceDire

Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage surface, providing boundary lubrication and preventing cell and protein adhesion.

Lubricin: a novel potential biotherapeutic approaches for the treatment of osteoarthritis | SpringerLi

Osteoarthritis (OA) is a multi-factor disorder of sinovial joints, which characterized by escalated degeneration and loss of articular cartilage. Treatment of OA is a critical unmet ...

Supramolecular synergy in the boundary lubrication of synovial joints | Nature Communicatio

with a very different role, to provide the boundary lubrication characteristic of healthy synovial joints: ... The role of lubricin in the mechanical behavior of synovial fluid. Proc. Natl Acad. Sci. USA 104, 6194–6199 (2007) . CAS PubMed Article 33. Linn, F . ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatment to prevent cartilage deterioration in patients ...

Transcription, Translation, and Function of Lubricin, a Boundary Lubricant, at the Ocular Surface | Cornea | JAMA Ophthalmology | JAMA Netwo

Lubricin plays a critical role as a boundary lubricant in articulating joints. 1-4 This amphiphilic glycoprotein, ... responsible for boundary mode lubrication at the ocular surface supports the hypothesis of Ehlers, 28 who theorized that boundary lubrication must 29 ...

The Role Of Lubricin And Galectins In Osteoarthritis And Cartilage Lubricati

The Role Of Lubricin And Galectins In Osteoarthritis And Cartilage Lubrication By Heidi Reesink Abstract ... and galectins-1 and -3 to determine if lubricin and galectins could synergistically enhance articular cartilage boundary lubrication and; 3) evaluate equine ...

Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury .

Objective To study the effect of anterior cruciate ligament (ACL) injury on lubricin concentrations in synovial fluid (SF) and its correlation with time postinjury ... Methods SF samples were obtained from both knees of 30 patients with unilateral ACL insufficiency, 32 ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Kimberly A. Wallera, Ling X. Zhangb, Khaled A. Elsaidc, Braden C. Fleminga,d,e, Matthew L. Warmanf,g, and Gregory D. Jaya,b,h,1 aCenter for Biomedical Engineering and the ...

NAVER Academic > Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosi

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Author Kimberly A Waller, Ling X Zhang, Khaled A Elsaid, Braden C Fleming, Matthew L Warman, Gregory D Jay Publisher ...

Proteoglycan 4 - Wikiped

Function Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP).

Lubricin: a novel potential biotherapeutic approaches for the treatment of osteoarthritis | SpringerLi

Osteoarthritis (OA) is a multi-factor disorder of sinovial joints, which characterized by escalated degeneration and loss of articular cartilage. Treatment of OA is a critical unmet ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apo

Title: Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Authors: Waller, K. A.; Zhang, L. X.; Elsaid, K. A.; Fleming, B. C.; Warman, M. L.; Jay, G. D. Publication: Proceedings of the National Academy of Sciences, vol. 110, issue ...

Regulation of lubricin for functional cartilage tissue regeneration: a review | Biomaterials Research | Full Te

The fundamental role of lubricin is lubrication of boundary surface of cartilage []. Hence, transmutation of lubricin metabolism would conspicuously influence joint performance. In fact, patients who suffer from osteoarthritis (OA), degenerative joint disease, or ...