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Relapsed classic E Cadherin CDH1 mutated invasive

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LobSig is a multigene predictor of outcome in invasive lobular carcinoma | npj Breast Canc

et al. ERBB2 mutation is associated with a worse prognosis in patients with CDH1 altered invasive lobular cancer of the breast ... Google Scholar 21. Ross, J. S. et al. Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a 19 ...

Lobular breast cancer: molecular basis, mouse and cellular models | Breast Cancer Research | Full Te

Ross JS, Wang K, Sheehan CE, Boguniewicz AB, Otto G, Downing SR, et al. Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations. Clin Cancer Res. 2013;19:2668–76. PubMed

Relapsed classic E-cadherin (CDH1) mutated invasive lobular breast cancer demonstrates a high frequency of HER2 (ERBB2) gene mutations | Clinical .

Purpose: We queried whether comprehensive genomic profiling using a next generation sequencing (NGS)-based assay could identify novel and unanticipated targets of therapy for patients with relapsed invasive lobular carcinoma (ILC). Experimental Design: DNA ...

CDH1 (gene) - Wikiped

Cadherin-1 also known as CAM 120/80 or epithelial cadherin (E-cadherin) or uvomorulin is a protein that in humans is encoded by the CDH1 gene. ...

(PDF) Relapsed classic E-Cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutatio

PDF | Purpose: We queried whether comprehensive genomic profiling using a next-generation sequencing-based assay could identify novel and unanticipated targets of therapy for patients with relapsed invasive lobular carcinoma (ILC). Experimental design: DNA ...

Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations | Read by Qx

PURPOSE: We queried whether comprehensive genomic profiling using a next-generation sequencing-based assay could identify novel and unanticipated targets of therapy for patients with relapsed invasive lobular carcinoma (ILC). EXPERIMENTAL DESIGN: DNA ...

A Neu View of Invasive Lobular Breast Canc

and colleagues performed next-generation sequencing on relapsed, invasive lobular breast cancer using a panel of 182 ... Wang K, Sheehan CE, Boguniewicz A, Otto G, Downing SR, et al. Relapsed classic E-cadherin (CDH1) mutated invasive lobular [] ...

Loss of function of NF1 is a mechanism of acquired resistance to endocrine therapy in lobular breast cancer | Annals of Oncology | Oxford Academ

Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations. Clin Cancer Res 2013; 19 (10): ...

Effects of UPF1 expression on EMT process by targeting E‑cadherin, N‑cadherin, Vimentin and Twist in a hepatocellular carcinoma cell li

Ross JS, Wang K, Sheehan CE, Boguniewicz AB, Otto G, Downing SR, Sun J, He J, Curran JA, Ali S, et al: Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations.

Oncotarget | ERBB2 mutation is associated with a worse prognosis in patients with CDH1 altered invasive lobular cancer of the brea

19. Ross JS, Wang K, Sheehan CE, Boguniewicz AB, Otto G, Downing SR, Sun J, He J, Curran JA, Ali S, Yelensky R, Lipson D, Palmer G et al. Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 20.

Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma | Nature Geneti

Although the majority of human ILCs are characterized by the functional loss of E-cadherin (encoded by CDH1), ... Ross, J.S. et al. Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2. 19 CAS ...

Frequent amplifications of ESR1, ERBB2 and MDM4 in primary invasive lobular breast carcinoma - ScienceDire

Invasive lobular carcinoma (ILC) represents the second most prevalent histological subtype of breast cancer after invasive ductal carcinoma (IDC), accounting for 10–15% of all invasive breast cancer. It is characterized by small, round cells, invading the adjacent].

Frequent alterations of HER2 through mutation, amplification, or overexpression in pleomorphic lobular carcinoma of the breast - Home - Spring

Ross JS, Wang K, Sheehan CE, Boguniewicz AB, Otto G, Downing SR, Sun J, He J, Curran JA, Ali S, Yelensky R, Lipson D, Palmer G, Miller VA, Stephens PJ (2013) Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high

clinical case of invasive lobular breast carcinoma with ERBB2 and CDH1 mutations presenting a dramatic response to anti ...- Oxford Academ

E-cadherin loss can be due to CDH1 mutation, which is observed in up to 83% of ILCs []. Interestingly, Ross et al. described an 18% of ERBB2 mutations (4/22) ...

Relapsed classic E-cadherin (CDH1) mutated invasive lobular breast cancer demonstrates a high frequency of HER2 (ERBB2) gene mutations - NBC 1

Relapsed classic E-cadherin (CDH1) mutated invasive lobular breast cancer demonstrates a high frequency of HER2 (ERBB2) gene mutations NBC 180 - A partir d'échantillons tumoraux prélevés sur 22 patientes atteintes d'un carcinome lobulaire invasif

Lobular breast cancer: molecular basis, mouse and cellular models | SpringerLi

... Wang K, Sheehan CE, Boguniewicz AB, Otto G, Downing SR, et al. Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2 ...

Treatment of Patients With Lobular Breast Cancer Harboring Human Epidermal Growth Factor Receptor 2 Mutation With HER2-Directed Therapy | JCO .

Ross JS, Wang K, Sheehan CE, et al: Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations. Clin Cancer Res 19: 2668-2676, 2013 Crossref, Google Scholar 6.

Genomic Characterization of Primary Invasive Lobular Breast Cancer | Journal of Clinical Oncolo

PurposeInvasive lobular breast cancer (ILBC) is the second most common histologic subtype after invasive ductal breast cancer (IDBC). ... JS Ross, K Wang, CE Sheehan, etal: Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows ...

A Neu View of Invasive Lobular Breast Cancer - Europe P

Ross JS, Wang K, Sheehan CE, Boguniewicz A, Otto G, Downing SR, et al. Relapsed classic E-cadherin (CDH1) mutated invasive lobular breast cancer demonstrates a high frequency of HER2 (ERBB2) gene mutations. Clin Cancer Res. 2013 []

Comprehensive molecular portraits of invasive lobular breast canc

E-cadherin loss in invasive lobular carcinoma Loss of the epithelial specific cell-cell adhesion molecule E-cadherin ... Sheehan CE, Boguniewicz AB, Otto G, Downing SR, Sun J, He J, Curran JA, Ali S, et al. Relapsed classic E-cadherin (CDH1)-mutated ...

Relapsed Classic E-Cadherin (CDH1 Mutated Invasive Lobular Breast Cancer Shows a High Frequency of HER2 ) Gene Mutatio

Human Cancer Biology Relapsed Classic E-Cadherin (CDH1)–Mutated Invasive Lobular Breast Cancer Shows a High Frequency of HER2 (ERBB2) Gene Mutations Jeffrey S. Ross1,2, Kai Wang 2, Christine E. Sheehan1, Ann B. Boguniewicz1, Geoff Otto , Sean R ...