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The role of recombination in telomere length maintenance | Biochemical Society Transactio

The connection between the minisatellite instability and the deregulation of recombination-based activity at telomeres is not understood, ... The role of recombination in telomere length maintenance Nicola J. Royle, Aarón Méndez-Bermúdez, Athanasia Gravani, ...

Recombination-Based Telomere Maintenance Is Dependent on Tel1-MRN and Rap1 and Inhibited by... - Europe PMC Article - Europe P

FULL TEXT Abstract: Fission yeast cells survive loss of the telomerase catalytic subunit Trt1 (TERT) through recombination-based telomere maintenance or through...

Recombination in telomere-length maintenance: Trends in Biochemical Scienc

Although telomerase is the major mechanism for telomere elongation in most cells, telomerase-independent mechanisms of telomere maintenance can allow cell survival. Yeast cells that lack telomerase maintain telomere length through a form of recombination known ...

DNA Recombination | SpringerLi

Homologous recombination is important in various aspects of DNA metabolism, including damage repair, replication, telomere maintenance, and meiosis, and yeast genetics has successfully provided a fram ... Homologous recombination is important in various ...

(PDF) Telomere maintenance is dependent on activities required for end repair of double-strand breaks | Giovanni Bosco - Academia.e

Academia.edu is a platform for academics to share research papers. ... Brief Communication 657 Telomere maintenance is dependent on activities required for end repair of double-strand breaks Constance I. Nugent*, Giovanni Bosco†, Lyle O. Ross*, Sara K ...

Telomere maintenance by telomerase and by recombination can coexist in human cells | Human Molecular Genetics | Oxford Academ

a rarer one based on telomere recombination [alternative lengthening of telomeres (ALT)]. ... from those with telomerase-negative yeast survivors in which reconstitution of enzyme activity consistently inhibits telomere maintenance by recombination ...

ALTernative Telomere Maintenance and Cancer: Trends in Canc

Activation of a telomere maintenance mechanism (TMM) is permissive for replicative immortality and a hallmark of human cancer. While most cancers rely on reactivation of telomerase, a significant fraction utilizes the recombination-dependent alternative lengthening ...

Telomere - Wikiped

These function in both telomere maintenance and capping. Telomeres form large loop structures called telomere loops, or T-loops. ... Population-based studies have also indicated an interaction between anti-oxidant intake and telomere length. In the Long Island ...

Section for Telomere Maintenance - National Institute on Agi

Section for Telomere Maintenance Yie Liu, Ph.D., Senior Investigator Telomeres are chromosome end capping structures that prevent chromosome termini from being recognized as broken DNA ends. Some age-related pathologies are associated with abnormal ...

Recombination Can either Help Maintain Very Short Telomeres or Generate Longer Telomeres in Yeast Cells with Weak Telomerase Activity | Eukaryotic .

The latter outcome likely represents a simplified form of recombinational telomere maintenance that is independent of the generation and copying of telomeric ...

Homologous recombination - Wikiped

BIR-like pathway helps to sustain some tumors by acting as an alternative mechanism of telomere maintenance. This fact has led scientists to investigate whether such recombination-based mechanisms of telomere maintenance could thwart anti-cancer. ...

ALTernative Telomere Maintenance and Cancer - ScienceDire

Alternative lengthening of telomeres (ALT) is a recombination-based telomere maintenance mechanism (TMM) utilized by 10–15% of human cancers. ALT is enriched in tumors of mesenchymal origin and often portends a poor prognosis. Clinical tests to identify ALT ...

Telomere maintenance by recombination in human cells | Nature Geneti

Non-telomerase mechanisms of telomere maintenance have been found in several eukaryotes. Drosophila melanogaster and related dipterans use retrotransposons for telomere maintenance 8. Homologous recombination is used for telomere maintenance in the ...

Targeting homologous recombination and telomerase in Barrett’s adenocarcinoma: Impact on telomere maintenance, genomic instability, and tumor grow

Targeting homologous recombination and telomerase in Barrett’s adenocarcinoma: Impact on telomere maintenance, genomic instability, and tumor growth The Harvard community has made this article openly available. Please share how this access benefits you.

Recombination-Based Telomere Maintenance Is Dependent on Tel1-MRN and Rap1 and Inhibited by Telomerase, Taz1, and Ku in Fission Yeast

Recombination-Based Telomere Maintenance Is Dependent on Tel1-MRN and Rap1 and Inhibited by Telomerase, Taz1, and Ku in Fission Yeast † Lakxmi Subramanian, Bettina A. Moser, and Toru M. Nakamura* Department of Biochemistry and Molecular ...

Recombination-Mediated Telomere Maintenance in Saccharomyces cerevisiae Is Not Dependent on the Shu Complex (pdf) | Paperi

Paperity: the 1st multidisciplinary aggregator of Open Access journals & papers. Free fulltext PDF articles from hundreds of disciplines, all in one place ... March Recombination-Mediated Telomere Maintenance in Saccharomyces cerevisiae Is Not Dependent on the ...

Short Telomeres Initiate Telomere Recombination in Primary and Tumor Cel

Our data suggest that, several distinct recombination-based mechanisms can contribute to telomere maintenance in mammalian cells. Materials and Methods Mice ...

Contributions of recombination and repair proteins to telomere maintenance in telomerase‐positive and negative Ustilago maydis - Yu - 2018 .

Homologous recombination and repair factors are known to promote both telomere replication and recombination‐based telomere extension. Herein, we address the diverse contributions of several recombination/repair proteins to telomere maintenance in Ustilago ...

ALTernative Telomere Maintenance and Cancer - ScienceDire

Alternative lengthening of telomeres (ALT) is a recombination-based telomere maintenance mechanism (TMM) utilized by 10–15% of human cancers. ALT is enriched in tumors of mesenchymal origin and often portends a poor prognosis. Clinical tests to identify ALT ...

Telomerase Can Inhibit the Recombination-based Pathway of Telomere Maintenance in Human Cells

Abstract Telomere length can be maintained by telomerase or by a recombination-based pathway. Because individual telomeres in cells using the recombination-based pathway of telomere maintenance appear to periodically become extremely short ...

ALTernative Telomere Maintenance and Canc

Alternative lengthening of telomeres (ALT) is a recombination-based telomere maintenance mechanism ... Boardman LA, et al. Correlation of chromosomal instability, telomere length and telomere maintenance in microsatellite stable rectal cancer: a molecular 8 ...